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The dental follicle, also known as dental sac, is made up of mesenchymal cells and fibres surrounding the enamel organ and dental papilla of a developing tooth. [1] It is a vascular fibrous sac [2] containing the developing tooth and its odontogenic organ. The dental follicle (DF) differentiates into the periodontal ligament.
The dental papilla contains cells that develop into odontoblasts, which are dentin-forming cells. [3] Additionally, the junction between the dental papilla and inner enamel epithelium determines the crown shape of a tooth. [2] The dental follicle gives rise to three important entities: cementoblasts, osteoblasts, and fibroblasts. Cementoblasts ...
B: dental papilla C: dental follicle. The tooth germ is an aggregation of cells that eventually forms a tooth. [2] These cells are derived from the ectoderm of the first pharyngeal arch and the ectomesenchyme of the neural crest. [1] [3] [4] The tooth germ is organized into three parts: the enamel organ, the dental papilla and the dental sac or ...
(1) The HERS, (2) epithelial rests of Malassez, (3) dental follicle, (4) cementoblasts, (5) periodontal ligament, (6) alveolar cells, (7) bone, (8) odontoblasts. In dentistry, the epithelial cell rests of Malassez (ERM) or epithelial rests of Malassez (pax epithelialis pediodontii) are part of the periodontal ligament cells around a tooth.
The dental follicle → The ectomesenchymal cells which are part of the fibrous sac that have been formed; The dental papilla → The ectomesenchymal cells which are lying deep to the enamel organ; The enamel organ → purely the epithelial component; The tissues which have been derived from each of the three components are:
The outer enamel epithelium, also known as the external enamel epithelium, is a layer of cuboidal cells located on the periphery of the enamel organ in a developing tooth. This layer is first seen during the bell stage. The rim of the enamel organ, where the outer and inner enamel epithelium join is called the cervical loop.
The Hertwig epithelial root sheath (HERS) or epithelial root sheath is a proliferation of epithelial cells located at the cervical loop of the enamel organ in a developing tooth. Hertwig epithelial root sheath initiates the formation of dentin in the root of a tooth by causing the differentiation of odontoblasts from the dental papilla.
It is thought that the central epithelial tissue of the cervical loop, the stellate reticulum, acts as a stem cell reservoir. In continuously growing teeth such as the rodent incisor the original structure of the cervical loop is maintained and no HERS forms. The stem cells provide the epithelial progeny to sustain the continuous growth.