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In 1986, it was presumed that permanent brain damage may result from chronic use of benzodiazepines similar to alcohol-related brain damage. [70] In 1987, 17 inpatient people who used high doses of benzodiazepines non-medically have anecdotally shown enlarged cerebrospinal fluid spaces with associated cerebral atrophy. Cerebral atrophy ...
This can occur both in the intoxicated state and during the withdrawal state. In some cases these substance-induced psychiatric disorders can persist long after detoxification from amphetamine, cocaine, opioid, and alcohol use, causing prolonged psychosis, anxiety or depression. A protracted withdrawal syndrome can occur with symptoms ...
Glutamate is an excitatory neurotransmitter that, in excessive amounts, causes excitotoxicity by promoting calcium influx into neurons. [8] This influx can lead to neuronal death, [8] contributing to brain damage of the emotional regulation and reward pathways in the prefrontal cortex, amygdala, and especially the hippocampus.
Reports have suggested that certain antidepressants can sometimes have weight gain as a side effect. A study recently published in the Annals of Internal Medicine examined weight changes related ...
[7] [65] Due to this sensitivity and NLPR3's role in triggering cytokine release, NLPR3 is thought to be a key component in sterile inflammatory responses, [7] something which has led to the suggestion that it is a likely mechanism linking non-pathogen induced stress to the increased inflammation that is common in depression and other forms of ...
Some antidepressants can cause “emotional blunting,” a new study finds. Here, mental health experts explain why it may happen, and what to do next.
Some antidepressants, including commonly prescribed ones from the class known as SSRIs (selective serotonin reuptake inhibitors), can cause sexual side effects such as erectile dysfunction ...
It is argued that this presents a risk of adverse effects, especially brain damage, in real-life mixed medication psychiatry that are not visible in the clinical trials of one medicine at a time (similar to mixed drug abuse causing significantly more damage than the additive effects of brain damages caused by using only one illegal drug ...
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