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Toxic oil syndrome (TOS) or simply toxic syndrome (Spanish: síndrome del aceite tóxico or síndrome tóxico) is a musculoskeletal disease.A 1981 outbreak in Spain which affected about 25,600 people, with over 4,000 dying within a few months and a few thousand remaining disabled, is thought to have been caused by contaminated colza (rapeseed) oil.
Diagram of deodorization tower The PCB that was used as the heating medium leaked from the pipes and mixed into the rice bran oil. Yushō disease (油症, lit. ' oil symptoms ') was a mass poisoning by polychlorinated biphenyls (PCBs) which occurred in northern Kyūshū, Japan, in 1968.
The modern oil is less toxic, but also less suitable for making oilcloth. Re-enactors may boil their own oil in the search for a correctly coloured oilcloth. [1] [2] Oilcloth used for weatherproofing may have used a mixture of lead and manganese salts, the sienna and umber pigments, to give a more humidity-resistant cure. [1]
The toxicity of petroleum related products threaten human health. Many compounds found in oil are highly toxic and can cause cancer (carcinogenic) as well as other diseases. [23] Studies in Taiwan link proximity to oil refineries to premature births. [26] Crude oil and petroleum distillates cause birth defects. [27]
Organic solvents that cause CSE are characterized as volatile, blood soluble, lipophilic compounds that are typically liquids at normal temperature. [ 2 ] [ 10 ] These can be compounds or mixtures used to extract, dissolve, or suspend non-water-soluble materials such as fats, oils, lipids, cellulose derivatives, waxes, plastics, and polymers.
Pulmonary toxicity: The decrease in glycogen levels following argemone oil intoxication could be due to enhanced glycogenolysis leading to the formation of glucose-1-phosphate, which enters the glycolytic pathway resulting in accumulation of pyruvate in the blood of experimental animals and dropsy patients.
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Acute toxicity describes the adverse effects of a substance that result either from a single exposure [1] or from multiple exposures in a short period of time (usually less than 24 hours). [ 2 ] To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance.