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These standards are adopted by the NCWM and published in Handbook 44: Specifications and Tolerances and Other Technical Requirements. NCWM utilizes special committees called National Type Evaluation Program Sectors to develop the technical policies, checklists and test procedures that are used for the evaluation and certification process.
Priority review is a program of the United States Food and Drug Administration (FDA) to expedite the review process for drugs that are expected to have a particularly great impact on the treatment of a disease. The priority review voucher program is a program that grants a voucher for priority review to a drug developer as an incentive to ...
Tolerance to infection, or disease tolerance, is a mechanism that host organisms can use to fight parasites or pathogens that attack the host. Tolerance is not equivalent to resistance. Disease resistance is the host trait that prevents infection or reduces the number of pathogens and parasites within or on a host.
Symptoms of infection vary from mild to severe, including fever, diarrhoea, and cough; the disease can often be fatal. [8] [9] The A/H7N9 virus is considered to be enzootic (continually present) in wild aquatic birds, which may carry the virus over large distances during their migration. [10]
Immune tolerance, also known as immunological tolerance or immunotolerance, refers to the immune system's state of unresponsiveness to substances or tissues that would otherwise trigger an immune response. It arises from prior exposure to a specific antigen [1] [2] and contrasts the immune system's conventional role in eliminating foreign antigens.
One may also develop drug tolerance to side effects, [7] in which case tolerance is a desirable characteristic. A medical intervention that has an objective to increase tolerance (e.g., allergen immunotherapy, in which one is exposed to larger and larger amounts of allergen to decrease one's allergic reactions) is called drug desensitization. [8]
Example of true position geometric control defined by basic dimensions and datum features. Geometric dimensioning and tolerancing (GD&T) is a system for defining and communicating engineering tolerances via a symbolic language on engineering drawings and computer-generated 3D models that describes a physical object's nominal geometry and the permissible variation thereof.
For example, if a shaft with a nominal diameter of 10 mm is to have a sliding fit within a hole, the shaft might be specified with a tolerance range from 9.964 to 10 mm (i.e., a zero fundamental deviation, but a lower deviation of 0.036 mm) and the hole might be specified with a tolerance range from 10.04 mm to 10.076 mm (0.04 mm fundamental ...