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Sjögren syndrome (an early symptom in some patients) [8] Medications that can cause overproduction of saliva include: [4] aripiprazole; clozapine; pilocarpine; ketamine; potassium chlorate; risperidone; pyridostigmine; Substances that can cause hypersalivation include: [4] mercury; copper; organophosphates (insecticide) arsenic; nicotine; thallium
Drooling or sialorrhea can occur during sleep. It is often the result of open-mouth posture from CNS depressants intake or sleeping on one's side. Sometimes while sleeping, saliva does not build up at the back of the throat and does not trigger the normal swallow reflex, leading to the condition.
Cases of the syndrome were first observed in three elderly female patients with presenile dementia. Each of these women were undergoing treatment with the antipsychotic drug methylperone, haloperidol or a combination of the two. The use of neuroleptic drugs caused the patients to exhibit a lateral flexion along with a rotation of the trunk.
A medication which is known to cause xerostomia may be termed xerogenic. [3] Over 400 medications are associated with xerostomia. [8] Although drug induced xerostomia is commonly reversible, the conditions for which these medications are prescribed are frequently chronic. [8]
Physostigmine, a cholinergic drug that readily crosses the blood–brain barrier, has been used as an antidote to treat the central nervous system depression symptoms of a scopolamine overdose. [33] Other than this supportive treatment , gastric lavage and induced emesis (vomiting) are usually recommended as treatments for oral overdoses. [ 32 ]
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Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.
The first 12-team College Football Playoff field was revealed on Sunday. Undefeated Oregon earned the top seed, while SMU beat out Alabama for the 12th and final spot. Oregon, Georgia, Boise State ...