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However, malignant cells can avoid this elimination by various mechanisms such as the loss of MHC I molecule, induction of anti-inflammatory tumor micro-environment, inhibition of T cell function, upregulation of ligands whose interactions with CD8 + T cell receptors results in their suppression etc. Immune checkpoint therapy and tumor ...
PRDM1/BLIMP-1 is a master transcription factor regulating downstream cytokines. It is activated by TLRs and IRF-4, and is crucial in T cell, B cell, and myeloid lineage cell differentiations.
The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate that reflects the yearly mean number of citations of articles published in the last two years in a given journal, as indexed by Clarivate's Web of Science.
AIRE is a transcription factor expressed in the medulla [broken anchor] (inner part) of the thymus. It is part of the mechanism which eliminates self-reactive T cells that would cause autoimmune disease. It exposes T cells to normal, healthy proteins from all parts of the body, and T cells that react to those proteins are destroyed.
Cellular Oncology is a bimonthly peer-reviewed medical journal published by Springer Science+Business Media. [1] The journal was established in 1989 as Analytical Cellular Pathology, obtaining its current name in 2003. [2] [3] It is an official publication of the International Society for Cellular Oncology and is published six times a year.
A growing body of evidence has shown links between cancer and drinking alcohol. In a warning Friday, U.S. Surgeon General Vivek Murthy said cancer risk increases with the number of drinks, but ...
While Donald Trump is returning to the White House with sweeping immunity from criminal prosecution, that won’t necessarily keep him out of the courtroom or free from testimony under oath.
Tyler Bilodeau scored 17 points, Skyy Clark added 15 and No. 24 UCLA rallied from a 13-point deficit midway through the second half to beat Arizona 57-54 on Saturday. UCLA won its eighth straight ...