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Benzamide is an organic compound with the chemical formula of C 7 H 7 NO. It is the simplest amide derivative of benzoic acid. In powdered form, it appears as a white solid, while in crystalline form, it appears as colourless crystals. [5] It is slightly soluble in water, [2] and soluble in many organic solvents. [6]
In animal studies, GTx-758 reversibly suppresses testosterone concentrations to castrate levels, reduces prostate size and levels of prostate-specific antigen (PSA), but does not induce typical side effects associated with hyperestrogenism (or hypoestrogenism) including hot flashes, bone loss, thrombophilia, hypercoagulation, or increased body fat. [1]
Trimethobenzamide is marketed under the brand names Tebamide and Tigan, manufactured by GlaxoSmithKline and King Pharmaceuticals, respectively.It is available as oral capsules and injectable formulations.
Research in men and women with Addison’s disease showed that 50 milligrams of DHEA a day for three months led to improved hormone levels, well-being, self-esteem, fatigue and mood. PeopleImages ...
GR-55562 is a selective serotonin 5-HT 1B and 5-HT 1D receptor antagonist. [1] It is one of several selective serotonin 5-HT 1B receptor antagonists used in scientific research. [2] [3]
Cinitapride (trade names Cintapro, Pemix) is a gastroprokinetic agent and antiemetic agent of the benzamide class which is marketed in India, Mexico, Pakistan and Spain. [1] [2] It acts as an agonist of the 5-HT 1 and 5-HT 4 receptors and as an antagonist of the 5-HT 2 receptors. [3] [4]
Tryptamine and serotonin are naturally occurring indole ethylamino compounds with pronounced pharmacological activities. They have served as the inspiration for synthesis of numerous analogues.
Medulloblastoma [20] [21] Advanced solid tumors (including ovarian, breast, pancreatic, stomach, oesophageal cancers and glioblastoma multiforme) [22] [23] [24] Acute leukemia [25] and chronic myeloid leukemia [26] Myelofibrosis and essential thrombocythaemia [27] It has demonstrated significant efficacy against melanoma in vitro and in vivo. [28]