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Throughout her tenure at the University of Rochester, Gorbunova's research team continued to focus on the naked mole rat as a key to understanding cancer resistance among animals. In 2013, Gorbunova and Seluanov identified high molecular weight hyaluronan as the key mediator of cancer resistance in the naked mole rat. [9]
The naked mole-rat (Heterocephalus glaber), also known as the sand puppy, [6] is a burrowing rodent native to the Horn of Africa and parts of Kenya, notably in Somali regions. It is closely related to the blesmols and is the only species in the genus Heterocephalus .
Cells of naked mole rats, a species in which cancer has never observed, show hypersensitivity to contact inhibition. [8] This finding may provide a clue to cancer resistance. Furthermore, recent studies have further revealed some mechanisms of contact inhibition of proliferation and its potential implications in cancer therapy.
It may look like a whiskered cocktail sausage, but the naked mole rat's incredible biology may one day improve countless lives. Meet the naked mole-rat: impervious to pain and cancer, and lives ...
Rochelle Buffenstein is an American comparative biologist currently working as Research Professor at the University of Illinois Chicago.Previously, she was a senior principal investigator at Calico Life Sciences, an Alphabet, Inc. funded research and development company investigating the biology that controls aging and lifespan where she used the extraordinarily long-lived cancer resistant ...
The closely related subfamily Spalacinae consists of mole-like rodents found in Africa and the Middle East; these are also myomorphic rodents. The family Bathyergidae , or African mole-rats (including the well-known naked mole-rat ), belong to the other major division of the rodents, the hystricomorphs.
Evidence supporting the theory started to crumble in the early 2000s. Mice with reduced expression of the mitochondrial antioxidant, SOD2, accumulated oxidative damage and developed cancer, but did not age faster. [33] Overexpression of antioxidants reduced cellular stress, but did not increase mouse life span.
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