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Cutaneous squamous-cell carcinoma is the second-most common cancer of the skin (after basal-cell carcinoma, but more common than melanoma). It usually occurs in areas exposed to the sun. Sunlight exposure and immunosuppression are risk factors for SCC of the skin, with chronic sun exposure being the strongest environmental risk factor. [26]
More than five million nonmelanoma skin cancers are diagnosed annually in the U.S., and an estimated 207,390 cases of melanoma will be diagnosed in 2021. Every hour more than two people die from skin cancer. [6] [7] The primary cause of skin cancer is ultraviolet (UV) radiation from the sun and indoor tanning beds. [8]
Skin cancer is the most commonly diagnosed form of cancer in humans. [11] [12] [13] There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. [1] The first two, along with a number of less common skin cancers, are known as nonmelanoma skin cancer (NMSC).
Keratoacanthoma is commonly found on sun-exposed skin, often face, forearms and hands. [2] [3] It is rarely found at a mucocutaneous junction or on mucous membranes. [2] Keratoacanthoma may be difficult to distinguish visually from a skin cancer. [4] Under the microscope, keratoacanthoma very closely resembles squamous cell carcinoma. In order ...
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With doctors who are experts in dermatoscopy, the diagnostic accuracy for melanoma is significantly better than those who do not have any specialized training. [3] Thus, there is considerable improvement in the sensitivity (detection of melanomas) as well as specificity (percentage of non-melanomas correctly diagnosed as benign), compared with naked eye examination.
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Skin Cancer: Recognition and Management is a clinical reference by Robert A. Schwartz covering skin and accessible mucosal disorders, premalignant and malignant cutaneous disorders, including melanoma, Kaposi's sarcoma and other sarcomas, cutaneous lymphoma, cutaneous metastatic disease and cutaneous markers of internal malignancy.