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Cytochrome c oxidase I (COX1) also known as mitochondrially encoded cytochrome c oxidase I (MT-CO1) is a protein that is encoded by the MT-CO1 gene in eukaryotes. [6] The gene is also called COX1, CO1, or COI. [7] Cytochrome c oxidase I is the main subunit of the cytochrome c oxidase complex.
Cyclooxygenase 1 (COX-1), also known as prostaglandin-endoperoxide synthase 1 (HUGO PTGS1), is an enzyme that in humans is encoded by the PTGS1 gene. [ 5 ] [ 6 ] In humans it is one of three cyclooxygenases .
COX subunits are encoded in both the nuclear and mitochondrial genomes. The three subunits that form the COX catalytic core are encoded in the mitochondrial genome. Over 30 different nuclear-encoded chaperone proteins are required for COX assembly. [12] Cofactors, including hemes, are inserted into subunits I & II.
COX is a common target for anti-inflammatory drugs. The most significant difference between the isoenzymes, which allows for selective inhibition, is the substitution of isoleucine at position 523 in COX-1 with valine in COX-2. The smaller Val 523 residue in COX-2 allows access to a hydrophobic side-pocket in the enzyme (which Ile 523 ...
Another group discovered a novel cDNA species encoding a protein with similar structure to COX-1 while studying phorbol-ester-induced genes in Swiss 3T3 cells. The same laboratory showed that this gene truly expressed a novel COX enzyme. The two enzymes were renamed COX-1, referring to the original enzyme and COX-2. [5]
12865 Ensembl ENSG00000161281 ENSMUSG00000074218 UniProt P24310 P56392 RefSeq (mRNA) NM_001864 NM_009944 RefSeq (protein) NP_001855 NP_034074 Location (UCSC) Chr 19: 36.15 – 36.15 Mb Chr 7: 29.88 – 29.89 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome c oxidase polypeptide 7A1, mitochondrial is an enzyme that in humans is encoded by the COX7A1 gene. Cytochrome c ...
The SCO2 gene encodes for a protein essential for the assembly and function of Mammalian cytochrome c oxidase (COX)(Complex IV) of the mitochondrial respiratory chain.SCO2 acts as a metallochaperone involved in the biogenesis of cytochrome c oxidase subunit II, an essential subunit of Complex IV which transfers the electrons from cytochrome c to the bimetallic center of the catalytic subunit 1 ...
Low-density parity-check (LDPC) codes are a class of highly efficient linear block codes made from many single parity check (SPC) codes. They can provide performance very close to the channel capacity (the theoretical maximum) using an iterated soft-decision decoding approach, at linear time complexity in terms of their block length.