Search results
Results from the WOW.Com Content Network
Several modifications of alkynylation reactions are known: In the Arens–van Dorp synthesis the compound ethoxyacetylene [7] is converted to a Grignard reagent and reacted with a ketone, the reaction product is a propargyl alcohol.
This alkynylation reaction is enantioselective and involves an alkynylzinc reagent [1] rather than the sodium acetylide used by John Ulric Nef in his 1899 report of the synthetic approach. [ 2 ] [ 3 ] Propargyl alcohols are versatile precursors for the chirally-selective synthesis of natural products and pharmaceutical agents , making this ...
A 3D model of ethyne (), the simplest alkyneIn organic chemistry, an alkyne is an unsaturated hydrocarbon containing at least one carbon—carbon triple bond. [1] The simplest acyclic alkynes with only one triple bond and no other functional groups form a homologous series with the general chemical formula C n H 2n−2.
English: Diagram showing the chemical reaction involving Sonogashira reaction of a phenylalanine derivative with an alkyne. Modified from File:Alkynylation.gif to correct chemical errors. Date
The reaction medium must be basic to neutralize the hydrogen halide produced as the byproduct of this coupling reaction, so alkylamine compounds such as triethylamine and diethylamine are sometimes used as solvents, but also DMF or ether can be used as solvent. Other bases such as potassium carbonate or cesium carbonate are occasionally used.
The Favorskii reaction is an organic chemistry reaction between an alkyne and a carbonyl group, under basic conditions. The reaction was discovered in the early 1900s by the Russian chemist Alexei Yevgrafovich Favorskii. [1] Favorskii reaction and the possible subsequent rearrangement
When bonded side-on to a single metal atom, an alkyne serves as a dihapto usually two-electron donor. For early metal complexes, e.g., Cp 2 Ti(C 2 R 2), strong π-backbonding into one of the π* antibonding orbitals of the alkyne is indicated.
Typical route for alkylation of benzene with ethylene and ZSM-5 as a heterogeneous catalyst. Alkylation is a chemical reaction that entails transfer of an alkyl group. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion, or a carbene (or their equivalents).