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Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of dementia; it usually occurs in old age. Familial Alzheimer's disease (FAD or EOFAD for early onset) is an inherited and uncommon form of AD. Familial AD usually strikes earlier in life, defined as before the age of 65.
“Alzheimer’s disease has a long pre-symptomatic period; Alzheimer’s-related changes take place in the brain 10, 15, even 20 years before the onset of memory and thinking symptoms.
One genetic variant associated with Alzheimer’s disease progression is presenilin 2 (PSEN2), which is correlated to an increased risk for early-onset familial Alzheimer’s disease (EOFAD ...
Early onset familial Alzheimer's disease can be attributed to mutations in one of three genes: those encoding amyloid-beta precursor protein (APP) and presenilins PSEN1 and PSEN2. [40] Most mutations in the APP and presenilin genes increase the production of a small protein called amyloid beta (Aβ)42, which is the main component of amyloid ...
Compared to late onset dementia, patients with early onset dementia are more likely to have dementias other than Alzheimer's disease, although Alzheimer's is the most common etiology in either case. [11] In general, early onset dementia has a faster progression and features more extensive neurological damage when compared to late onset dementia.
Some people are genetically predisposed to develop early-onset Alzheimer’s disease before the age of 65. Researchers from Mass General Brigham have discovered a genetic variant that may help ...
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