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Calcitonin. Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates [5] in the ultimopharyngeal body. [6] It acts to reduce blood calcium (Ca 2+), opposing the effects of parathyroid hormone (PTH). [7]
A substance called calcitonin gene-related peptide (CGRP) has been shown to be involved in the development of migraine by widening blood vessels in the brain. [3] Galcanezumab is a monoclonal antibody (a type of protein) designed to attach to and block CGRP, thereby helping blood vessels to return to their normal size. [ 3 ]
Ubrogepant is a small-molecule calcitonin gene-related peptide receptor antagonist. [7][8] It is the first drug in this class approved for the acute treatment of migraine. The most common side effects are nausea, tiredness and dry mouth. [6] Ubrogepant is contraindicated for co-administration with strong CYP3A4 inhibitors.
Calcitonin gene-related peptide (CGRP) receptor antagonists are a class of drugs that act as antagonists of the calcitonin gene-related peptide receptor (CGRPR). [1] Several monoclonal antibodies that bind to the CGRP receptor or peptide have been approved for prevention of migraine. [2] Nerve activation triggers the release of CGRP and other ...
InterPro. Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 (intermedin) and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by thyroid C cells whilst CGRP is secreted and stored in the nervous system. [1]
Dual amylin and calcitonin receptor agonists (DACRAs) are a class of drugs that act as agonists at the amylin receptor and calcitonin receptor that are under development as therapies for obesity and type 2 diabetes. Examples are cagrilintide and the KBP family derived from salmon calcitonin, [1] including KBP‐042, [2] KBP-066A, [3] KBP-089 ...
Atogepant. Atogepant, sold under the brand name Qulipta among others, is a medication used to prevent migraines. [4][5] It is a gepant, an orally active calcitonin gene-related peptide receptor antagonist. [4][7] The most common side effects include nausea, constipation, tiredness, somnolence (sleepiness), decreased appetite, and decreased weight.
Eptinezumab. Eptinezumab, sold under the brand name Vyepti, is a medication used for the preventive treatment of migraine in adults. [6] It is a monoclonal antibody that targets calcitonin gene-related peptides (CGRP) alpha and beta. [6][8][9] It is administered by intravenous infusion every 3 months. [6]