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Drug withdrawal, drug withdrawal syndrome, or substance withdrawal syndrome [1] is the group of symptoms that occur upon the abrupt discontinuation or decrease in the intake of pharmaceutical or recreational drugs. In order for the symptoms of withdrawal to occur, one must have first developed a form of drug dependence.
Where risks or harms is the reason for withdrawal, this will usually have been prompted by unexpected adverse effects that were not detected during Phase III clinical trials, i.e. they were only made apparent from postmarketing surveillance data collected from the wider community over longer periods of time.
The comedown, or crashing (also "down", "low", or sometimes "crash"), is a phase of drug withdrawal that involves the deterioration in mood and energy that occurs when a psychoactive drug, typically a stimulant, [1] clears from the blood in the bloodstream.
Coitus interruptus, also known as withdrawal, pulling out or the pull-out method, is an act of birth control during penetrative sexual intercourse, whereby the penis is withdrawn from a vagina prior to ejaculation so that the ejaculate may be directed away in an effort to avoid insemination.
Sudden withdrawal from drugs such as alcohol, benzodiazepines, and barbiturates can be extremely dangerous, leading to potentially fatal seizures. For long-term alcoholics, going cold turkey can cause life-threatening delirium tremens. [1] In the case of opioid withdrawal, going "cold turkey" is extremely unpleasant but less dangerous.
The withdrawal rate depends on several factors, such as your portfolio’s size and living expenses. Retiring early is possible, and may be easier than you think. Click here now to see if you’re ...
The British National Formulary recommends a gradual withdrawal when discontinuing antipsychotics to avoid acute withdrawal syndrome or rapid relapse. [19] Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite. [20] Other symptoms may include restlessness, increased sweating, and trouble sleeping. [20]
A new report from Morningstar recommends the safe withdrawal rate for retirees in 2025 is a mere 3.7% — a significant adjustment from the decades-old 4% rule that had dominated retirement planning.