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Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene. [5] [6] It is responsible for the distribution of melanin pigment in mammals.[7] [8] Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin (a brown to black pigment). [9]
An agouti dog, also called wolf sable. In dogs, the agouti gene is associated with various coat colors and patterns. [10]The alleles at the A locus are related to the production of agouti-signaling protein (ASIP) and determine whether an animal expresses an agouti appearance and, by controlling the distribution of pigment in individual hairs, what type of agouti.
AgRP is a paracrine signaling molecule made of 112 amino acids (the gene product of 132 amino acids is processed by removal of the N-terminal 20-residue signal peptide domain). It was independently identified by two teams in 1997 based on its sequence similarity with agouti signalling peptide (ASIP), a protein synthesized in the skin ...
Agouti, an animal of order Rodentia it was named after; Agouti-signaling protein, the protein encoded by the agouti (ASIP) gene; Agouti coloration genetics, an overview of different animal coat colors caused by differences in the agouti gene
The agouti factor determines the "background" of the tabby coat, which consists of hairs that are banded with dark eumelanin and lighter phaeomelanin along the length of the hair shaft. The Agouti gene, with its dominant A allele and recessive a allele, controls the coding for agouti signaling protein (ASIP; ).
The bay horse, left, has both eumelanin and phaeomelanin in her coat; the agouti signaling peptide suppresses black color to the "points" v the mane, tail, ear tips, and legs. The horse at right lacks the agouti signalling protein, and has a uniformly black or aphaeomelanistic coat.
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The agouti gene codes for a molecule called the agouti-signaling protein, or ASIP. This molecule interacts with MC1R, the receptor coded by extension, to block the signal for black pigment production. [12] The signal for black pigment comes from a melanocyte-stimulating hormone, which is present throughout the horse. [2]