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Benfotiamine (rINN, or S-benzoylthiamine O-monophosphate) is a synthetic, fat-soluble, S-acyl derivative of thiamine (vitamin B1) that is approved in some countries as a medication or dietary supplement to treat diabetic sensorimotor polyneuropathy. Benfotiamine was developed in late 1950s in Japan.
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B1 is typically only water soluble. Note that a substance can also be fat and water soluble, although there is no indication that benfotiamine is such a substance. --IO Device 18:42, 6 November 2011 (UTC) benfotiamine is a fat soluble form of thiamine. B1 is tradiitonally considered water soluble because most B1 is in the thiamine form.
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Alpha lipoic acid (ALA) with benfotiamine is a proposed pathogenic treatment for painful diabetic neuropathy only. [119] The results of two systematic reviews state that oral ALA produced no clinically significant benefit, intravenous ALA administered over three weeks may improve symptoms and that long-term treatment has not been investigated ...
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A 2007 review of studies found ... Benfotiamine is an oral prodrug of Vitamin B1 that has several placebo-controlled double-blind trials proving efficacy in ...
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