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During terminal differentiation, a precursor cell formerly capable of cell division permanently leaves the cell cycle, dismantles the cell cycle machinery and often expresses a range of genes characteristic of the cell's final function (e.g. myosin and actin for a muscle cell). Differentiation may continue to occur after terminal ...
Due to the differentiation in function, somatic cells are found only in multicellular organisms, as in unicellular ones the purposes of somatic and germ cells are consolidated in one cell. All organisms with germ-soma differentiation are eukaryotic , and represent an added level of specialization to multicellular organisms.
Newer cell fate determination techniques include lineage tracing performed using inducible Cre-lox transgenic mice, where specific cell populations can be experimentally mapped using reporters like brainbow, a colorful reporter that is useful in the brain and other tissues to follow the differentiation path of a cell. [15]
[12] [13] Subsequently, new cells derived from yolk sac will be established between trophoblast and exocoelomic membrane and will give rise to extra-embryonic mesoderm, which will form the chorionic cavity. [11] At the end of the second week of development, some cells of the trophoblast penetrate and form rounded columns into the ...
Undifferentiated cells have not completed differentiation or specialization, thus retaining their cell potency and oftentimes being highly proliferative. [19] This is often the final cell state after the dedifferentiation process is completed and maintained, as cells become less specialized.
Cell differentiation relates specifically to the formation of functional cell types such as nerve, muscle, secretory epithelia, etc. Differentiated cells contain large amounts of specific proteins associated with cell function. Morphogenesis relates to the formation of a three-dimensional shape. It mainly involves the orchestrated movements of ...
The cell cycle is a four-stage process that a cell goes through as it develops and divides. It includes Gap 1 (G1), synthesis (S), Gap 2 (G2), and mitosis (M). The cell either restarts the cycle from G1 or leaves the cycle through G0 after completing the cycle. The cell can progress from G0 through terminal differentiation.
Embryonic stem cells exhibit dramatic and complex alterations to both global and site-specific chromatin structures. Lee et al. performed an experiment to determine the importance of deacetylation and acetylation for stem cell differentiation by looking at global acetylation and methylation levels at certain site-specific modification in histone sites H3K9 and H3K4.
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