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Renal oncocytoma of the right kidney at CT. Renal oncocytomas are often asymptomatic and are frequently discovered by chance on a CT or ultrasound of the abdomen. Possible signs and symptoms of a renal oncocytoma include blood in the urine , flank pain, and an abdominal mass.
An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. [ 1 ] [ 2 ] The cells and the tumor that they compose are often benign but sometimes may be premalignant or malignant .
The RENAL Nephrometry Scoring System is used to measure the complexity of kidney tumors for determining whether a renal mass is appropriate for partial or radical nephrectomy, and is estimated by CT scan as follows: [7] The nephrometery score takes into account the size of the tumor (Radius), how much of the tumor is inside or outside of the ...
Kidney cancer, also known as renal cancer, is a group of cancers that starts in the kidney. [4] Symptoms may include blood in the urine, a lump in the abdomen, or back pain. [1] [2] [3] Fever, weight loss, and tiredness may also occur. [1] [2] [3] Complications can include spread to the lungs or brain. [6]
Hybrid oncocytoma/chromophobe renal cell carcinoma is rare subtype of renal cell carcinoma. [1] It arises from intercalated cells of cortical collecting ducts of the kidney. It is associated with extreme hypodiploidy with multiple losses of entire chromosomes 1, 2, 6, 10, 13, 17, 21 and Y. [ citation needed ]
The average number of kidney tumors found in a person with BHD is 5.3, though up to 28 tumors have been found. [7] Hybrid oncocytoma/chromophobe carcinoma, found in 50% of cases, [8] is the most commonly found cancer, followed by chromophobe renal carcinoma, clear cell renal carcinoma, renal oncocytoma, and papillary renal cell carcinoma.
Chronic kidney disease (associated with growth impairment) Genetic conditions (including Turner Syndrome, Prader-Willi Syndrome, SHOX gene haploinsufficiency, and Noonan Syndrome)
Oncocytes (left of image), as seen in a renal oncocytoma. H&E stain. An oncocyte is an epithelial cell characterized by an excessive number of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. Oncocytes can be benign or malignant.