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Renal oncocytoma of the right kidney at CT. Renal oncocytomas are often asymptomatic and are frequently discovered by chance on a CT or ultrasound of the abdomen. Possible signs and symptoms of a renal oncocytoma include blood in the urine , flank pain, and an abdominal mass.
An salivary gland oncocytoma (also known as an oxyphilic adenoma) is a well-circumscribed, benign neoplastic growth comprising about one percent of all salivary gland tumors. The histopathology is marked by sheets of large, swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei.
Oncocytes (left of image), as seen in a renal oncocytoma. H&E stain. An oncocyte is an epithelial cell characterized by an excessive number of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. Oncocytes can be benign or malignant.
The RENAL Nephrometry Scoring System is used to measure the complexity of kidney tumors for determining whether a renal mass is appropriate for partial or radical nephrectomy, and is estimated by CT scan as follows: [7] The nephrometery score takes into account the size of the tumor (Radius), how much of the tumor is inside or outside of the ...
Gross examination of a kidney (right of image) with a renal oncocytoma (left of image).. Gross processing, "grossing" or "gross pathology" is the process by which pathology specimens undergo examination with the bare eye to obtain diagnostic information, as well as cutting and tissue sampling in order to prepare material for subsequent microscopic examination.
Post-operatively, the presence of renin granules in pathology specimens as well as immunohistochemical analyses could help differentiating this tumor from other primary renal tumors such as hemangiopericytoma, glomus tumor, metanephric adenoma, epithelioid angiomyolipoma, Wilms tumor, solitary fibrous tumor, and some epithelial neoplasms. [6] [8]
The average number of kidney tumors found in a person with BHD is 5.3, though up to 28 tumors have been found. [7] Hybrid oncocytoma/chromophobe carcinoma, found in 50% of cases, [8] is the most commonly found cancer, followed by chromophobe renal carcinoma, clear cell renal carcinoma, renal oncocytoma, and papillary renal cell carcinoma.
Hybrid oncocytoma/chromophobe renal cell carcinoma is rare subtype of renal cell carcinoma. [1] It arises from intercalated cells of cortical collecting ducts of the kidney. It is associated with extreme hypodiploidy with multiple losses of entire chromosomes 1, 2, 6, 10, 13, 17, 21 and Y. [ citation needed ]