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Scheme of the complement system. The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]
Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components.
The binding of C2 and C4b results in C2 being cleaved by C1s into C2a and C2b. C2b diffuses into the plasma as a protein inflammatory mediator while C2a remains attached with C4b, forming the C3-convertase (C4b2a). The function of the membrane-bound C3-convertase is the cleavage of many many molecules of C3 into C3a and C3b.
The nines' complement of a decimal digit is the number that must be added to it to produce 9; the nines' complement of 3 is 6, the nines' complement of 7 is 2, and so on, see table.
The volume of such a mixture is slightly less than the sum of the volumes of the components. Thus, by the above definition, the term "40% alcohol by volume" refers to a mixture of 40 volume units of ethanol with enough water to make a final volume of 100 units, rather than a mixture of 40 units of ethanol with 60 units of water.
A panel of global experts explains why BMI is not the most helpful measurement of body weight, and how else doctors can diagnose obesity. Image credit: VICTOR TORRES/Stocksy.
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The hyperbolic volume of the figure-eight knot is 2.0298832. In the mathematical field of knot theory, the hyperbolic volume of a hyperbolic link is the volume of the link's complement with respect to its complete hyperbolic metric. The volume is necessarily a finite real number, and is a topological invariant of the link. [1]