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The biggest risk factor for osteoarthritis seems to be age, and often the cartilage degrades over longer periods of time, which makes it really hard to pinpoint one single culprit. As I mentioned earlier, inflammation also seems to be involved, and there are a number of proinflammatory cytokines like IL-1, IL-6, and TNF, among others, that seem ...
Osteoarthritis commonly affects the hands, feet, spine, and the large weight-bearing joints, such as the hips and knees, although in theory, any joint in the body can be affected. As osteoarthritis progresses, movement patterns (such as gait), are typically affected. [1] Osteoarthritis is the most common cause of a joint effusion of the knee. [15]
There are common risk factors that increase a person's chance of developing arthritis later in adulthood. Some of these are modifiable while others are not. [2] [3] Some common risk factors that can increase the chances of developing osteoarthritis include obesity, prior injury to the joint, type of joint, and muscle strength. [50] [51]
Cartilage in the knee may begin to break down after sustained stress, leaving the bones of the knee rubbing against each other and resulting in osteoarthritis. [7] Nearly a third of US citizens are affected by osteoarthritis of the knee by age 70. [8] Obesity is a known and very significant risk factor for the development of osteoarthritis. [9]
Inflammatory arthritis is a group of diseases which includes: rheumatoid arthritis, psoriatic arthropathy, inflammatory bowel disease, adult-onset Still's disease, scleroderma, juvenile idiopathic arthritis, and systemic lupus erythematosus (SLE). [1]
[1] [2] A set of proposed causal mechanisms are represented as pie charts where each pie in the diagram represent a theoretical causal mechanism for a given disease, which is also called a sufficient cause. [3] Each pie is made up of many component factors, otherwise known as component causes represented by sectors in the diagram. In this ...
Trapeziometacarpal osteoarthritis (TMC OA) is, also known as osteoarthritis at the base of the thumb, thumb carpometacarpal osteoarthritis, basilar (or basal) joint arthritis, or as rhizarthrosis. [ 3 ] [ 1 ] [ 2 ] This joint is formed by the trapezium bone of the wrist and the metacarpal bone of the thumb.
Osteoarthritis and Cartilage is monthly peer-reviewed medical journal covering research in orthopedics and rheumatology. It is an official journal of the Osteoarthritis Research Society International , published on their behalf by Elsevier .