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Alcohol can exacerbate the symptoms and may directly contribute to increased severity of symptoms. The reasons for toxicity vary depending on the mixture of drugs. Usually, most victims die after using two or more drugs in combination that suppress breathing, and the low blood oxygen level causes brain death. [6]
Alcohol has an additive effect when combined with zopiclone, enhancing the adverse effects including the overdose potential of zopiclone significantly. [ 51 ] [ 52 ] Due to these risks and the increased risk for dependence, alcohol should be avoided when using zopiclone.
Symptoms of varying BAC levels. Additional symptoms may occur. The short-term effects of alcohol consumption range from a decrease in anxiety and motor skills and euphoria at lower doses to intoxication (drunkenness), to stupor, unconsciousness, anterograde amnesia (memory "blackouts"), and central nervous system depression at higher doses.
Alcohol intoxication leads to negative health effects due to the recent drinking of large amount of ethanol (alcohol). [6] [20] When severe it may become a medical emergency. Some effects of alcohol intoxication, such as euphoria and lowered social inhibition, are central to alcohol's desirability. [21]
Before taking temazepam, one should ensure that at least 8 hours are available to dedicate to sleep. Failing to do so can increase the side effects of the drug. Like all benzodiazepines, the use of this drug in combination with alcohol potentiates the side effects, and can lead to toxicity and death.
Common side effects include daytime sleepiness, headache, nausea, and diarrhea. [11] More severe side effects include memory problems and hallucinations . [ 7 ] While flumazenil , a GABA A –receptor antagonist , can reverse zolpidem's effects, usually supportive care is all that is recommended in overdose.
Zolpidem tartrate, a common but potent sedative–hypnotic drug.Used for severe insomnia. Hypnotic (from Greek Hypnos, sleep [1]), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep [2] (or surgical anesthesia [note 1]) and to treat insomnia (sleeplessness).
Benzodiazepines can cause death when mixed with other CNS depressants such as opioids, alcohol, or barbiturates. [7] [8] [9] GHB combined with alcohol can lead to a long-lasting coma-like state (‘G-sleep’) or even accidental death, particularly in light of GHB's narrow threshold for overdose. Depressants combined with stimulants. For example: