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Nanoparticles of gadolinium oxide is a potential contrast agent for magnetic resonance imaging (MRI). A dextran-coated preparation of 20–40 nm sized gadolinium oxide particles had a relaxivity of 4.8 s −1 mM −1 per gadolinium ion at 7.05 T (an unusually high field compared to the clinically used MRI scanners which mostly range from 0.5 to ...
Because Mn 2+ ions can enter cells through calcium transport channels, it has been used for functional brain imaging. [66] Manganese(III) chelates with porphyrins and phthalocyanines have also been studied. [61] Unlike the other well-studied iron oxide-based nanoparticles, research on Mn-based nanoparticles is at a relatively early stage. [67]
It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd 3+), and is used in form of the meglumine salt (gadoterate meglumine). [ 4 ] [ 5 ] The paramagnetic property of gadoteric acid reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in MRI , which is the source of its clinical utility.
However, gadolinium can be found on rare occasions in the 0, +1 and +2 oxidation states. All four trihalides are known. All are white, except for the iodide, which is yellow. Most commonly encountered of the halides is gadolinium(III) chloride (GdCl 3). The oxide dissolves in acids to give the salts, such as gadolinium(III) nitrate.
A 2015 study found gadolinium deposited in the brain tissue of people who had received gadodiamide. [8] Other studies using post-mortem mass spectrometry found most of the deposit remained at least 2 years after an injection and deposit also in individuals with no kidney issues. In vitro studies found it to be neurotoxic. [9]
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The decahydrate of gadolinium oxalate thermally decomposes to obtain the anhydrous form, which can then be heated to produce gadolinium oxide. [2] Gadolinium oxalate reacts with hydrochloric acid to produce Gd(C 2 O 4)Cl. [3] It also reacts with sodium hydroxide under hydrothermal conditions to produce gadolinium hydroxide. [1]
Gadolinium salts are of primary interest for relaxation agents in magnetic resonance imaging . This technique exploits the fact that Gd 3+ has an electronic configuration of f 7 . Seven is the largest number of unpaired electron spins possible for an atom, so Gd 3+ is a key component in the design of highly paramagnetic complexes. [ 6 ]