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Quaternary structure of the CD123 protein. The interleukin-3 receptor is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system. The gene coding for the receptor is located in the pseudoautosomal region of the X and Y chromosomes.
3563 16188 Ensembl ENSG00000185291 ENSMUSG00000068758 UniProt P26951 P26952 RefSeq (mRNA) NM_001267713 NM_002183 NM_008369 RefSeq (protein) NP_001254642 NP_002174 NP_032395 Location (UCSC) Chr X: 1.34 – 1.38 Mb Chr 14: 8.11 – 8.12 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (C luster of D ifferentiation ...
Receptor tyrosine-protein kinase erbB-2, HER2 (human epidermal growth factor receptor 2) or HER2/neu. Overexpression plays a role in certain types of breast cancer. It is a biomarker target for breast cancer drugs such as Herceptin. CD344: FZD4 (Frizzled-4) a receptor in WNT-signalling pathway and for Norrin.
The CD nomenclature was proposed and established in the 1st International Workshop and Conference on Human Leukocyte Differentiation Antigens (HLDA), held in Paris in 1982. [4] [5] This system was intended for the classification of the many monoclonal antibodies (mAbs) generated by different laboratories around the world against epitopes on the surface molecules of leukocytes (white blood cells).
Cancers that possess the B7-H3 immunoregulatory checkpoint receptor on the tumor cell have been one such target in clinical trials. This B7-H3 protein is expressed on cancer cell for several types of cancer. Often, the drug will contain two domains, one binding the T-cell's CD3 and the other targeting and binding cancer cells.
This pathway can be triggered via two mechanisms: physiological stimulus (like reduced O2 tension) and activation of the prostacyclin receptor (IPR). This pathway includes heterotrimeric G proteins, adenylyl cyclase (AC), protein kinase A (PKA), cystic fibrosis transmembrane conductance regulator (CFTR), and a final conduit that transport ATP ...
Neurotransmitter receptor – membrane receptor that can be activated by a neurotransmitter. Interactions between neurotransmitters and neurotransmitter receptors can evoke a wide range of differing responses from the cell receiving the signal, including excitation, inhibition, and various types of modulation. Category:Receptors
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin-12 (IL-12) with a low affinity, and is part of the IL-12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL-12 binding activity.