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2C-B (4-bromo-2,5-dimethoxyphenethylamine), also known as Nexus, is a synthetic psychedelic drug of the 2C family, mainly used as a recreational drug. [2] [1] [4] It was first synthesized by Alexander Shulgin in 1974 for use in psychotherapy.
While found only in the peripheral nervous system, a report does indicate that CB 2 is expressed by a subpopulation of microglia in the human cerebellum. [20] CB 2 receptors appear to be responsible for immunomodulatory [19] and possibly other therapeutic effects of cannabinoid as seen in vitro and in animal models. [18]
These effects are common for most psychedelics in the substituted phenethylamine class. There is a strong similarity between the subjective effects caused by βk-2C-B and 2C-B. However, βk-2C-B is often described to be more stimulating and less psychedelic. This, combined with its long duration, could increase the perceived severity of the ...
There are two known subtypes of cannabinoid receptors, termed CB 1 and CB 2. [6] [7] The CB 1 receptor is expressed mainly in the brain (central nervous system or "CNS"), but also in the lungs, liver and kidneys. The CB 2 receptor is expressed mainly in the immune system, in hematopoietic cells, [8] and in parts of the brain. [9] The protein ...
A dried cannabis flower. The short-term effects of cannabis are caused by many chemical compounds in the cannabis plant, including 113 [clarification needed] different cannabinoids, such as tetrahydrocannabinol, and 120 terpenes, [1] which allow its drug to have various psychological and physiological effects on the human body.
This activity at CB 1 and CB 2 receptors constitutes interaction of CBN with the endocannabinoid system (ECS). Although CBN shares the same mechanism of action as other phytocannabinoids (e.g., Delta-9-tetrahydrocannabinol , Δ 9 -THC), it has a lower affinity for CB 1 receptors, meaning that much higher doses of CBN are required in order to ...
25B-NBOMe (NBOMe-2C-B, Cimbi-36, Nova, BOM 2-CB) is a derivative of the phenethylamine psychedelic 2C-B, discovered in 2004 by Ralf Heim at the Free University of Berlin. It acts as a potent full agonist for the 5HT 2A receptor .
Although CBG is sold as a dietary supplement, its effects and safety for human consumption are unknown. [2] Safety concerns have been raised due to the potent activation of α 2 -adrenergic receptors by CBG, which may produce sedation and potentially undesirable cardiovascular effects like decreased heart rate and blood pressure .