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Scarlet fever serum from horses' blood was used in the treatment of children beginning in 1900 and reduced mortality rates significantly. [ 64 ] In 1906, Austrian pediatrician Clemens von Pirquet postulated that disease-causing immune complexes were responsible for the nephritis that followed scarlet fever.
The ASOT helps direct antimicrobial treatment and is used to assist in the diagnosis of scarlet fever, rheumatic fever, and post infectious glomerulonephritis. [citation needed] A positive test usually is > 200 units/mL, [1] but normal ranges vary from laboratory to laboratory and by age. [2] The false negatives rate is 20 to 30%. [1]
Early recognition and treatment are critical; diagnostic failure can result in sepsis and death. [5] [6] S. pyogenes is clinically and historically significant as the cause of scarlet fever, which results from exposure to the species' exotoxin. [7]
The treatment of choice is penicillin, and the duration of treatment is around 10 days. [23] Antibiotic therapy (using injected penicillin) has been shown to reduce the risk of acute rheumatic fever. [24] In individuals with a penicillin allergy, erythromycin, other macrolides, and cephalosporins have been shown to be effective treatments. [25]
The first stage of scarlet fever is typically strep throat (streptococcal pharyngitis) characterized by sore throat, fever, headache and sometimes nausea and vomiting. In two to three days, this is followed by the appearance of a diffuse erythematous rash that has a sandpaper texture.
A 7-year-old girl who was treated for the flu and scarlet fever died hours after she was discharged from an Indiana hospital last week. Matthew Jessie told People that his young daughter, Savanna ...
This compared quite favorably when measured against the 13.09% among children in Vienna hospitals where the scarlet fever serum was not administered. Moser's antitoxin reduced the mortality of scarlet fever by 40%. At no time was the volume of serum available sufficient. As of November 1902 a strong concentrated scarlet fever serum was ...
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