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It is a disease involving the defective transepithelial transport of cystine and dibasic amino acids in the kidney and intestine and is one of many causes of kidney stones. If not treated properly, the disease could cause serious damage to the kidneys and surrounding organs, and in some rare cases death.
Samoyeds can be affected by basement membrane disease of the kidneys. It is inherited through the X chromosome and is therefore more severe in affected male dogs. Findings in male dogs include the presence of protein and glucose in the urine and the inability to concentrate urine, and progression to kidney failure by the age of 9 months and death by 16 months. [3]
The disease has been shown to be a model for Alport syndrome in humans [1] in that the disease resembles that of the human disease. Because of this, it is sometimes referred to by the name given to the disease in humans when referring to the conditions in Samoyed dogs. Alternatively, it may also be known as X-linked hereditary nephritis.
It can result in chronic kidney failure, hypoalbuminemia, which can cause ascites and peripheral edema, and nephrotic syndrome, which can cause hypertension or hypercoagulability. [156] Familial renal disease is an uncommon cause of kidney failure in young dogs. Most causes are breed-related (familial) and some are inherited.
This disease is also caused by other diseases and toxins that damage the kidney. Both acute and chronic tubulointerstitial nephritis can be caused by a bacterial infection in the kidneys known as pyelonephritis , but the most common cause is by an adverse reaction to a medication.
Urinary tract infections are commonly associated with bladder stones. Smaller stones may become lodged in the urethra, especially in male animals, causing urinary tract obstruction and the inability to urinate. This condition causes acute kidney failure, hyperkalemia, sepsis, and death within a few days.
Alabama rot, Greenetrack disease, or cutaneous and renal glomerular vasculopathy (CRGV) [1] is an often fatal condition in dogs. It was first identified in the US in the 1980s in greyhounds. [2] [3] The high number of affected dogs at the Greenetrack Racing Park, Alabama, led to the initial pseudonyms of Greenetrack Disease and Alabama Rot. [4]
[65] [66] During urinary tract infections, waste products of bacterial metabolism can cause the urine to become alkaline. [67] Urine pH may be monitored to help prevent the formation of kidney stones or to avoid side effects of some drugs, [ 68 ] such as high-dose methotrexate therapy, in which crystals that cause kidney damage can form if the ...
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