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The COPII coat consists of an inner layer – a flexible meshwork of Sar1, Sec23, and Sec24 – and an outer layer made of Sec13 and Sec31. [1] Sar1 resembles other Ras-family GTPases, with a core of six beta strands flanked by three alpha helices , and two flexible "switch domains".
Electron micrograph of in vitro–formed COPI-coated vesicles. Average vesicle diameter at the membrane level is 60 nm. COPI is a coatomer, a protein complex [1] that coats vesicles transporting proteins from the cis end of the Golgi complex back to the rough endoplasmic reticulum (ER), where they were originally synthesized, and between Golgi compartments.
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER.
The involvement of the heterotetramer of COPI is similar to that of the AP/clathrin situation, but the coat of COPI is not closely related to the coats of either CCVs or COPII vesicles. [ 16 ] [ 17 ] AP-5 is associated with 2 proteins, SPG11 and SPG15 , which have some structural similarity to clathrin , and may form the coat around the AP-5 ...
COPI is a coatomer that coats the vesicles transporting proteins from the Golgi complex to the ER. [4] This pathway is referred to as retrograde transport. Before the COP I protein can coat vesicles on the Golgi membrane, it must interact with a small GTPase called ARF1 (ADP ribosylation factor). [5]
There are three types of vesicle coats: clathrin, COPI and COPII. The various types of coat proteins help with sorting of vesicles to their final destination. Clathrin coats are found on vesicles trafficking between the Golgi and plasma membrane, the Golgi and endosomes and the plasma membrane and endosomes. COPI coated vesicles are responsible ...
A recent report [1] has shown that the initial interaction between TRAPP and the ER derived vesicle is mediated via the interaction between the TRAPP subunit Bet3 and the COPII coat subunit, Sec23. The conventional view of tethering/fusion assumed that the vesicle coat is shed prior to tethering and fusion but this report argues for a model ...
69608 Ensembl ENSG00000150961 ENSMUSG00000039234 UniProt O94855 n/a RefSeq (mRNA) NM_014822 NM_001318066 NM_027135 RefSeq (protein) NP_001304995 NP_055637 n/a Location (UCSC) Chr 4: 118.72 – 118.84 Mb Chr 3: 123.06 – 123.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Protein transport protein Sec24D is a protein that in humans is encoded by the SEC24D gene. The protein ...