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  2. Discovery and development of direct thrombin inhibitors

    en.wikipedia.org/wiki/Discovery_and_development...

    In October 2010 the US FDA approved dabigatran etexilate for the prevention of stroke in patients with atrial fibrillation (AF). [6] [10] Many pharmaceutical companies have attempted to develop orally bioavailable DTI drugs but dabigatran etexilate is the only one to reach the market. [9]

  3. Dabigatran - Wikipedia

    en.wikipedia.org/wiki/Dabigatran

    Dabigatran was approved for medical use in the United States in 2010. [6] It is on the World Health Organization's List of Essential Medicines. [10] In 2020, it was the 306th most commonly prescribed medication in the United States, with more than 1 million prescriptions. [11] Dabigatran is available a generic medication. [12] [13]

  4. Direct factor Xa inhibitors - Wikipedia

    en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

    Factors considered before deciding on whether warfarin or a DOAC or which direct factor Xa inhibitor is used, include: the presence or absence of valvular heart disease, state of kidney function, the risk of stroke and the risk of bleeding. [8]

  5. Drug overdose deaths down in Ohio, but increase in ... - AOL

    www.aol.com/drug-overdose-deaths-down-ohio...

    After Stark County reported its sixth consecutive increase in overdose deaths in 2023, local health officials say 2024 appears promising. Drug overdose deaths down in Ohio, but increase in Stark ...

  6. Ohio betters nation in reduction of overdose deaths - AOL

    www.aol.com/ohio-betters-nation-reduction...

    The Ohio Department of Health’s annual Unintentional Drug Overdose Report showed a 9% decline in verified overdose deaths across the state. In 2023, there were 4,452 unintentional drug overdose ...

  7. Drug overdose deaths down in Ohio. Fentanyl, opioids remain ...

    www.aol.com/drug-overdose-deaths-down-ohio...

    Fewer Ohioans are dying of drug overdoses because of better access to naloxone, opioid treatment and peer support, Gov. Mike DeWine said Wednesday.

  8. Vitamin K antagonist - Wikipedia

    en.wikipedia.org/wiki/Vitamin_K_antagonist

    We undertook a post-hoc analysis of data from the ROCKET AF (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation, n = 14,624) for stroke or non-CNS embolism within 30 days after temporary interruptions of 3 days or more, early permanent ...

  9. Stroke may cause 10 million deaths a year globally by 2050 ...

    www.aol.com/news/stroke-may-cause-10-million...

    Costs associated with stroke in the US could hit $2.3 trillion by 2050, up from $891 billion in 2020 Stroke may cause 10 million deaths a year globally by 2050, new research finds Skip to main content

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