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History of aspirin. Aspirin (acetylsalicylic acid), an organic compound that does not occur in nature, was first synthesised in 1899. In 1897, scientists at the drug and dye firm Bayer began investigating acetylated organic compounds as possible new medicines, following the success of acetanilide ten years earlier.
[13]: 69–75 [18] By 1899, Bayer had named it "Aspirin" and was selling it around the world. [19] Aspirin's popularity grew over the first half of the 20th century, leading to competition between many brands and formulations. [20] The word Aspirin was Bayer's brand name; however, its rights to the trademark were lost or sold in many countries ...
Felix Hoffmann (21 January 1868 – 8 February 1946) was a German chemist notable for re-synthesising diamorphine (independently from C.R. Alder Wright who synthesized it 23 years earlier), which was popularized under the Bayer trade name of "heroin". He is also credited with synthesizing aspirin, though whether he did this under his own ...
A new DNA test suggests they might have even self-prescribed an early version of a common modern day painkiller.
Edward Stone was born in Princes Risborough, Buckinghamshire, England, in 1702. His parents were Edward Stone, a gentleman farmer, and his first wife Elizabeth Reynolds. His mother having died, his father took a second wife, Elizabeth Grubb, in 1707; the Grubb family was to play a major role in Stone's life. [ 1]
In 1833 French chemist Anselme Payen was the first to discover an enzyme, diastase. In 1834, François Mothes and Joseph Dublanc created a method to produce a single-piece gelatin capsule that was sealed with a drop of gelatin solution. In 1853 Alexander Wood was the first physician that used hypodermic needle to dispense drugs via Injections.
Additionally, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduces leukocyte adhesion, which is an important step in immune response to infection. There is currently insufficient evidence to show that aspirin helps to fight infection. [17]
1908 – Victor Horsley and R. Clarke invents the stereotactic method. 1909 – First intrauterine device described by Richard Richter. [102] 1910 – Hans Christian Jacobaeus performs the first laparoscopy on humans. 1917 – Julius Wagner-Jauregg discovers the malarial fever shock therapy for general paresis of the insane.