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Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma. [1][2][3][4][5] It is denoted by the abbreviation . [2][4] This is used to measure the removal of ...
Clearance (pharmacology) In pharmacology, clearance ( ) is a pharmacokinetic parameter representing the efficiency of drug elimination. This is the rate of elimination of a substance divided by its concentration. [1] The parameter also indicates the theoretical volume of plasma from which a substance would be completely removed per unit time.
In pharmacokinetics, steady state refers to the situation where the overall intake of a drug is fairly in dynamic equilibrium with its elimination. In practice, it is generally considered that once regular dosing of a drug is started, steady state is reached after 3 to 5 times its half-life. In steady state and in linear pharmacokinetics, AUC ...
Area under the curve (pharmacokinetics) In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry [1]). In practice, the drug concentration is measured at certain discrete points ...
The pharmacokinetics of estradiol, including its bioavailability, metabolism, biological half-life, and other parameters, differ by route of administration. [10] Likewise, the potency of estradiol, and its local effects in certain tissues, most importantly the liver, differ by route of administration as well. [10]
The elimination half-life of testosterone in the blood or by intravenous injection is only about 10 minutes. [ 8 ] [ 33 ] Conversely, testosterone and testosterone esters in oil solution or crystalline aqueous suspension administered by intramuscular or subcutaneous injection have much longer half-lives, in the range of days to months, due to ...
Elimination rate constant. The elimination rate constant K or Ke is a value used in pharmacokinetics to describe the rate at which a drug is removed from the human system. [1] It is often abbreviated K or Ke. It is equivalent to the fraction of a substance that is removed per unit time measured at any particular instant and has units of T −1.
Effective half-life. In pharmacokinetics, the effective half-life is the rate of accumulation or elimination of a biochemical or pharmacological substance in an organism; it is the analogue of biological half-life when the kinetics are governed by multiple independent mechanisms. This is seen when there are multiple mechanisms of elimination ...