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The treatment and management of COVID-19 combines both supportive care, which includes treatment to relieve symptoms, fluid therapy, oxygen support as needed, [1][2][3] and a growing list of approved medications. Highly effective vaccines have reduced mortality related to SARS-CoV-2; however, for those awaiting vaccination, as well as for the ...
The catalytic residues (His41, Cys145) are shown as yellow sticks. Nirmatrelvir is an antiviral medication developed by Pfizer which acts as an orally active 3C-like protease inhibitor. [3][4][5][6][7] It is part of a nirmatrelvir/ritonavir combination used to treat COVID-19 and sold under the brand name Paxlovid. [8]
COVID-19. Pfizer. 3C-like protease inhibitor (Nirmatrelvir) / inhibition of metabolism of nirmatrelvir (ritonavir) Nevirapine. HIV. non- nucleoside reverse transcriptase inhibitor. Nitazoxanide. Broad-spectrum antiviral.
Azithromycin, sold under the brand names Zithromax (in oral form) and Azasite (as an eye drop), is an antibiotic medication used for the treatment of a number of bacterial infections. [10] This includes middle ear infections, strep throat, pneumonia, traveler's diarrhea, and certain other intestinal infections. [10]
Nirmatrelvir/ritonavir has been evaluated in the treatment of COVID‑19 in standard-risk individuals in the EPIC-SR trial. [48] [50] This study did not achieve its primary goal of reducing time to sustained alleviation of COVID‑19 symptoms (treatment: 13 days (95% CI 12–15 days); placebo: 13 days (95% CI 11–14 days)).
The drug repurposing analysis that was first to propose a steroid for severe COVID-19 case was eventually published in the journal Bioinformatics [185] Currently, steroids including methylprednisolone and dexamethasone are part of the standard of care in severe cases of COVID-19.
Remdesivir is the first treatment for COVID‑19 to be approved by the U.S. Food and Drug Administration (FDA). [60] The approval by the FDA does not include the entire population that had been authorized to use remdesivir under an Emergency Use Authorization (EUA) originally issued in May 2020. [60]
The Randomised Evaluation of COVID-19 Therapy ( RECOVERY Trial) [ 1] is a large-enrollment clinical trial of possible treatments for people in the United Kingdom admitted to hospital with severe COVID-19 infection. [ 2][ 3][ 4] The trial was later expanded to Indonesia, Nepal and Vietnam. [ 5] The trial has tested ten interventions on adults ...
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