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Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [7] [10] It is used to treat major depressive disorder, obsessive compulsive disorder, panic disorder, and social phobia. [7] The antidepressant effects may take one to four weeks to occur. [7]
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder; sertraline and fluvoxamine were later approved for it as well. Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [22]
Saphris – atypical antipsychotic used to treat schizophrenia and bipolar disorder; Serax – anti-anxiety medication of the benzodiazepine class, often used to help during detoxification from alcohol or other addictive substances; Serentil (mesoridazine) – an antipsychotic drug used in the treatment of schizophrenia [1]
SERT occupancy by SRIs at clinically approved dosages Medication Dosage range (mg/day) [4] ~80% SERT occupancy (mg/day) [5] [6] Ratio (dosage / 80% occupancy) Citalopram: 20–40: 40: 0.5–1 Escitalopram: 10–20: 10: 1–2 Fluoxetine: 20–80: 20: 1–4 Fluvoxamine: 50–350: 70: 0.71–5 Paroxetine: 10–60: 20: 0.5–3 Sertraline: 25–200: ...
A separate survey conducted last year by researchers at the University of Michigan found that about 1 in 4 adults surveyed, ages 50 to 80, reported taking aspirin regularly, around three or more ...
Doctors used to recommend taking a low-dose aspirin daily, but this has changed in recent years. ... doctors recommended that older adults at a higher risk for heart attack or stroke take a low ...
Andersen et al. were able to generate a model of the (S)-citalopram binding site in human SERT by combining mutational analysis and comparative modeling where they found out that Asn-177 and Phe-341 where key determinants for (S)-citalopram potency and high affinity inhibition [47] in addition to Tyr-95, Asp-98, Ile-172 and Ser438 previously ...
Timeline of approved SNRIs. There are eight FDA approved SNRIs in the United States, with venlafaxine being the first drug to be developed in 1993 and levomilnacipran being the latest drug to be developed in 2013. The drugs vary by their other medical uses, chemical structure, adverse effects, and efficacy. [6]