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Onychomycosis does not necessarily require treatment. [3] The antifungal medication terbinafine taken by mouth appears to be the most effective but is associated with liver problems. [2] [5] Trimming the affected nails when on treatment also appears useful. [2] There is a ciclopirox-containing nail polish, but there is no evidence that it works ...
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They work in a similar way as azoles but have their effects earlier on in the ergosterol synthesis pathway. Allylamines allow the active ingredients in the medication to accumulate well within the stratum corneum of the skin and nails to exert their actions. They inhibit the enzyme squalene epoxidase which converts squalene into ergosterol.
The fungus was first isolated in 1870 from a tinea cruris patient in Germany by Carl Otto Harz, who named it Acrothecium floccosum. [10] Being unaware of Harz's work, Castellani and Sabouraud identified the species again in 1905 and 1907, respectively, and both placed the fungus into the genus Epidermophyton. [11]
An antifungal medication, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others.
Fluconazole is an antifungal medication used for a number of fungal infections. [5] This includes candidiasis, blastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, dermatophytosis, and tinea versicolor. [5]
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Preventive measures include wearing a face mask in dusty areas, avoiding contact with water-damaged buildings, and protecting the skin from exposure to soil such as when gardening or certain outdoor work. [10] It tends to progress rapidly and is fatal in about half of sinus cases and almost all cases of the widespread type. [2] [19]
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