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  2. Febuxostat - Wikipedia

    en.wikipedia.org/wiki/Febuxostat

    Febuxostat, sold under the brand name Uloric among others, is a medication used long-term to treat gout due to high uric acid levels. [7] It is generally recommended only for people who cannot take allopurinol .

  3. Lesinurad - Wikipedia

    en.wikipedia.org/wiki/Lesinurad

    Lesinurad (brand name Zurampic) is a urate transporter inhibitor for treating high blood uric acid levels associated with gout. [2] It is recommended only as an adjuvant with either allopurinol or febuxostat when these medications are not sufficient.

  4. Drug resistance - Wikipedia

    en.wikipedia.org/wiki/Drug_resistance

    An illustrative diagram explaining drug resistance. Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in treating a disease or condition. [1] The term is used in the context of resistance that pathogens or cancers have "acquired", that is, resistance has evolved.

  5. Xanthine oxidase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Xanthine_oxidase_inhibitor

    A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism.In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions including gout. [1]

  6. Cluster of drug-resistant mpox identified in five states, US ...

    www.aol.com/news/cluster-drug-resistant-mpox...

    The drug-resistant mpox cases follow an initial, unrelated cluster reported in California in late 2022-early 2023, and are the first involving multiple states, according to the report.

  7. Uricosuric - Wikipedia

    en.wikipedia.org/wiki/Uricosuric

    Drugs with other primary uses, that have known uricosuric properties, include losartan, [1] atorvastatin, and fenofibrate.Although these drugs may have significant uricosuric action, their other significant pharmacological actions in off-label use as a uricosuric requires careful assessment of the patient to achieve the most benefit and least risk.

  8. Trump's agenda in trouble? What the Republican revolt on ...

    www.aol.com/trumps-agenda-trouble-republican...

    Massie predicted other Trump policy proposals would pass without GOP resistance under the right circumstances. "I mean, if you put a bill to fund the (border) wall on the floor on January 3 that ...

  9. 29-Year-Old in ‘Catatonic State’ After Rare Disorder Causes ...

    www.aol.com/lifestyle/29-old-catatonic-state...

    A 29-year-old man’s debilitating night terrors were the first sign of rare autoimmune disorder that rapidly progressed, landing him in the intensive care unit in a “catatonic state.” Ben ...