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The best-selling statin is atorvastatin, also known as Lipitor, which in 2003 became the best-selling pharmaceutical in history. [12] The manufacturer Pfizer reported sales of US$12.4 billion in 2008. [13] Patient compliance with statin usage is problematic despite robust evidence of the benefits. [14] [15]
The first synthesis of atorvastatin at Parke-Davis that occurred during drug discovery was racemic followed by chiral chromatographic separation of the enantiomers. An early enantioselective route to atorvastatin made use of an ester chiral auxiliary to set the stereochemistry of the first of the two alcohol functional groups via a ...
In the European Union, icosapent ethyl is indicated to reduce cardiovascular risk as an adjunct to statin therapy. [4]In the United States, icosapent ethyl is indicated as an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable angina requiring hospitalization in adults with elevated triglyceride levels (≥ ...
Employment Division, Department of Human Resources of Oregon v. Smith, 494 U.S. 872 (1990), is a United States Supreme Court case that held that the state could deny unemployment benefits to a person fired for violating a state prohibition on the use of peyote even though the use of the drug was part of a religious ritual.
Smith v. United States, 508 U.S. 223 (1993), is a United States Supreme Court case that held that the exchange of a gun for drugs constituted "use" of the firearm for purposes of a federal statute imposing penalties for "use" of a firearm "during and in relation to" a drug trafficking crime.
Davis v. United States, 512 U.S. 452 (1994), was a United States Supreme Court case in which the Court established that the right to counsel can only be legally asserted by an "unambiguous or unequivocal request for counsel." [1] Legal scholars have criticized this case stating that the "bright line" rule established under Edwards v.
Smith v. Arizona, 602 U.S. 779 (2024), is a decision of the Supreme Court of the United States case in which the court held that when an expert conveys an absent analyst's statements in support of the expert's opinion, and the statements provide that support only if true, then the statements come into evidence for their truth.
Davis v. United States, 564 U.S. 229 (good-faith exception to the exclusionary rule) Davis v. United States, 512 U.S. 452 (invocation of the right to counsel under Miranda) Davis v. United States, 495 U.S. 472 (charitable deductions under §170 of the Internal Revenue Code) Davis v. United States (1974), 417 U.S. 333; Davis v. United States ...