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The first synthesis of atorvastatin at Parke-Davis that occurred during drug discovery was racemic followed by chiral chromatographic separation of the enantiomers. An early enantioselective route to atorvastatin made use of an ester chiral auxiliary to set the stereochemistry of the first of the two alcohol functional groups via a ...
The best-selling statin is atorvastatin, also known as Lipitor, which in 2003 became the best-selling pharmaceutical in history. [12] The manufacturer Pfizer reported sales of US$12.4 billion in 2008. [13] Patient compliance with statin usage is problematic despite robust evidence of the benefits. [14] [15]
Davis v. United States, 512 U.S. 452 (1994), was a United States Supreme Court case in which the Court established that the right to counsel can only be legally asserted by an "unambiguous or unequivocal request for counsel." [1] Legal scholars have criticized this case stating that the "bright line" rule established under Edwards v.
United States Supreme Court cases titled Davis v. United States: Davis v. United States, 589 U.S. ___ (2020), a per curiam opinion; Davis v. United States, 564 U.S. 229 (good-faith exception to the exclusionary rule) Davis v. United States, 512 U.S. 452 (invocation of the right to counsel under Miranda) Davis v.
Davis v. United States , 564 U.S. 229 (2011), was a case in which the Supreme Court of the United States "[held] that searches conducted in objectively reasonable reliance on binding appellate precedent are not subject to the exclusionary rule ". [ 1 ]
Davis v. United States, 411 U.S. 233 (1973), was a 1973 United States Supreme Court case concerning criminal procedure and collateral attacks on criminal convictions. The majority opinion, authored by then-Associate Justice William Rehnquist, held that when claims of unconstitutional jury discrimination are brought on postconviction collateral review, they are subject to the timeliness ...
The Supreme Court of the United States is the only court specifically established by the Constitution of the United States, implemented in 1789; under the Judiciary Act of 1789, the Court was to be composed of six members—though the number of justices has been nine for most of its history, this number is set by Congress, not the Constitution ...
In a case involving a state law prohibiting corporate expenditures that support or oppose a political candidate or party, the Supreme Court reversed the Montana Supreme Court's 2011 holding in Western Tradition Partnership, Inc. v. Attorney General of Montana that the law did not violate the First Amendment.