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Carbimazole (brand names Neo-Mercazole, Anti-Thyrox, etc.) is used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole . Methimazole prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin , hence reducing the production of the ...
The most common drugs in this class are thioamides, which include propylthiouracil, methimazole and its prodrug carbimazole. Additionally, propylthiouracil may reduce the de-iodination of thyroxine (T 4) into triiodothyronine (T 3) in peripheral tissues. [2] Lugol's iodine is used to temporarily block thyroid hormone synthesis before surgeries. [3]
The three main anti-thyroid drugs, known as thioureylenes, are methimazole, carbimazole, and propylthiouracil. Carbimazole is converted to methimazole by the body. These drugs concentrate within the thyroid gland and inhibit the ability of iodide and iodothyronines to form thyroxine and triiodothyronine which prevents thyroid synthesis. These ...
Carbimazole, drug used to treat hyperthyroidism; Mafenide, a sulfonamide-type medication used as an antibiotic This page was last edited on 21 August 2020, at 23:30 ...
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