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1-Ethynylcyclohexanol (ECX) is an alkynyl alcohol derivative which is both a synthetic precursor to, and an active metabolite of the tranquilizer ethinamate, and has similar sedative, anticonvulsant and muscle relaxant effects. It has been sold as a designer drug, first being identified in the UK in March 2012. [1] [2] [3] [4]
Ethinamate (1-ethynylcyclohexanone carbamate) is synthesized by combining acetylene with cyclohexanone to make 1-ethynylcyclohexanol, and then transforming this into a carbamate by the subsequent reaction with phosgene, and later with ammonia. Some lithium metal or similar is used to make the acetylene react with the cyclohexanone in the first ...
Toggle the table of contents. Clocental. 2 languages ... (6-4-3-5-7-10)15-9(14 ... Clocental was first prepared by the acylation of 1-ethynylcyclohexanol with ...
The epoxidation can take place either in a homogeneous reaction by peracids [2] or heterogeneous catalysis (e.g. silver and molecular oxygen). [ 3 ] [ 4 ] [ 5 ] In industrial production the heterogeneously catalyzed synthesis is preferred because of better atom economy , a simpler separation of the product and easier recycling of catalyst.
1-Hexanol (IUPAC name hexan-1-ol) is an organic alcohol with a six-carbon chain and a condensed structural formula of CH 3 (CH 2) 5 OH. This colorless liquid is slightly soluble in water, but miscible with diethyl ether and ethanol .
Hantzsch ester refers to an organic compound with the formula HN(MeC=C(CO 2 Et)) 2 CH 2 where Me = methyl (CH 3) and Et = ethyl (C 2 H 5). It is a light yellow solid. The compound is an example of a 1,4-dihydropyridine. It is named after Arthur Rudolf Hantzsch who described its synthesis in 1881.
The reaction is named after Russian organic chemist Vyacheslav Tishchenko, who discovered that aluminium alkoxides are effective catalysts for the reaction. [1] [2] [3] In the related Cannizzaro reaction, the base is sodium hydroxide and then the oxidation product is a carboxylic acid and the reduction product is an alcohol.
This could explain why reactions of the monomeric TMP-Turbo-Hauser base are much faster than that of dimeric iPr-Turbo-Hauser base. The regioselective ortho deprotonation reactions of TMPMgCl·LiCl could stem from a sufficient complex-induced proximity effect (CIPE) between the bimetallic aggregate and the functionalized (hetero)aromatic substrate.