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As a result of demineralization, the bones become less rigid. Physical signs include deformities like triradiate pelvis [14] and lordosis. The patient has a typical "waddling" gait. However, these physical signs may derive from a previous osteomalacial state, since bones do not regain their original shape after they become deformed.
These growth factors modulate the differentiation of progenitor cells into osteoprogenitor cells, which are responsible for bone and cartilage formation. As a result of the demineralization process, DBM is more biologically active than undemineralized bone grafts; conversely the mechanical properties are significantly diminished. [citation needed]
Demineralization is the opposite process of mineralization; it is a process of reduction in the mineral content in tissue or an organism. Examples include bone demineralization or tooth demineralization. Demineralization can lead to serious diseases such as osteoporosis, rickets, or tooth decay. [1]
A bone density test may detect osteoporosis or osteopenia. [4] The usual response to either of these indications is consultation with a physician. [4] Bone density tests are not recommended for people without risk factors for weak bones, [5] [4] which is more likely to result in unnecessary treatment rather than discovery of a weakness.
To confirm the diagnosis, renal osteodystrophy must be characterized by determining bone turnover, mineralization, and volume (TMV system) [2] (bone biopsy). [16] All forms of renal osteodystrophy should also be distinguished from other bone diseases which may equally result in decreased bone density (related or unrelated to CKD): osteoporosis [19]
This results in an increased bone resorption rate and a decreased bone mineral density due to increased pit numbers and pit areas in the bone. [18] [19] [20] Research has shown that viable osteocytes (another type of bone cell) may prevent osteoclastogenesis, whereas apoptotic osteocytes tend to induce osteoclast stimulation. Stimulation of ...
The cells of our bone that is involved in bone formation and bone breakdown is osteoblast and osteoclast respectively. Osteoclasts are cells of bones that promote bone demineralization or bone resorption. [3] In contrast, Osteoblast promotes calcium absorption by the bone therefore, promoting bone mineralization and formation of new bones. [2]
Demineralisation or demineralization may refer to: Demineralization (physiology) Bone demineralisation leading to osteoporosis; see Bone mineralization; Tooth demineralisation that leads to dental caries; see Remineralisation of teeth; Demineralizing (silk worm cocoon)