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The sustained expression of VCAM-1 lasts over 24 hours. Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of integrins. VCAM-1 expression has also been observed in other cell types (e.g., smooth muscle cells). It has also been shown to interact with EZR [7] and Moesin. [7]
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In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events. [1] The ICAM family consists of five members, designated ICAM-1 to ICAM-5.
They include soluble isoforms of the cell adhesion molecules ICAM-1, VCAM-1, E-selectin and P-selectin (distinguished as sICAM-1, sVCAM-1, sE-selectin and sP-selectin). The cellular expression of CAMs is difficult to assess clinically, but these soluble forms are present in the circulation and may serve as markers for CAMs.
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VLA-4's primary ligands include VCAM-1 and fibronectin. [4] One activating chemokine is SDF-1 . Following SDF-1 binding, the integrin undergoes a conformational change of the alpha and beta domains that is necessary to confer high binding affinity for the endothelial adhesion molecules.
Series Premiere date Last Aired Notes Aaha: 7 May 2012 14 September 2012 Agni Satchi: 2001 2002 [4]Anbudan Kushi: 27 January 2020 14 August 2021 Andal Azhagar