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An outcome measure, endpoint, effect measure or measure of effect is a measure within medical practice or research, (primarily clinical trials) which is used to assess the effect, both positive and negative, of an intervention or treatment. [1] [2] Measures can often be quantified using effect sizes. [3]
This subversion has been the justification for repeated attempts to improve process and thus outcomes by reorganizing the structure of health care, wittily described by Oxman et al. [16] Donabedian himself cautioned that outcomes measurement cannot distinguish efficacy from effectiveness: (outcomes may be poor because the right treatment is ...
Clinical endpoints or clinical outcomes are outcome measures referring to occurrence of disease, symptom, sign or laboratory abnormality constituting a target outcome in clinical research trials. The term may also refer to any disease or sign that strongly motivates withdrawal of an individual or entity from the trial, then often termed a ...
The c. 1847 work of Ignaz Semmelweis on the association between puerperal fever and the absence of aseptic procedures (specifically, doctors who failed to clean their hands before delivering babies) and the subsequent use of calcium hypochlorite to reduce risk, is an early example of outcomes research.
The term core domain is a key aspect of health or well-being that is considered essential to define, measure and report in all clinical trials and other research studies related to a specific health condition or disease.These are considered the ‘What’ to measure in Core Outcome Sets. [5]
The ATE measures the difference in mean (average) outcomes between units assigned to the treatment and units assigned to the control. In a randomized trial (i.e., an experimental study), the average treatment effect can be estimated from a sample using a comparison in mean outcomes for treated and untreated units.
PROMIS has worked to unify the field of patient-reported outcome (PRO) measurement through the promotion of a common, systematic measurement system broadly applicable across clinical research. PROMIS measures are intended to assess the most common or salient dimensions of patient–relevant outcomes for the widest possible range of chronic ...
Thus the concept of an outcome does not necessarily mean that the program targets have actually changed or that the program has caused them to change in any way. [8] There are two kinds of outcomes, namely outcome level and outcome change, also associated with program effect. [8] Outcome level refers to the status of an outcome at some point in ...