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Sabizabulin, as an orally available molecule, acts on microtubules, a component of the cytoskeleton.It binds to the colchicine binding site on the beta subunit of tubulin, as well as a novel site on the alpha subunit, and causes both to crosslink, thus depolymerizing microtubules and preventing their polymerization. [9]
The discovery of tocotrienols was first reported by Pennock and Whittle in 1964, describing the isolation of tocotrienols from rubber. [13] The biological significance of tocotrienols was clearly delineated in the early 1980s, when its ability to lower cholesterol was first reported by Asaf Qureshi and Elson in the Journal of Medicinal Chemistry. [14]
In psychology, self-efficacy is an individual's belief in their capacity to act in the ways necessary to reach specific goals. [1] The concept was originally proposed by the psychologist Albert Bandura in 1977.