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Tenofovir alafenamide is a nucleotide reverse transcriptase inhibitor and is a prodrug of tenofovir. It was developed by Gilead Sciences based on the protide technology of Chris McGuigan and is applied in the form of tenofovir alafenamide fumarate (TAF).
Monitor for tenofovir toxicity. Lopinavir/ritonavir, atazanavir coadministered with ritonavir & darunavir coadministered with ritonavir May increase tenofovir concentrations. Ledipasvir/sofosbuvir: May increase tenofovir concentrations. Consider alternative Hepatitis C antiviral or antiretroviral therapy. Monitor for tenofovir toxicity.
Tenofovir disoproxil can be taken by mouth and is sold under the brand name Viread, among others. [31] Tenofovir disoproxil is a pro-drug form of tenofovir phosphonate, which is liberated intracellularly and converted to tenofovir disphophate. [32] It is marketed by Gilead Sciences (as the fumarate, abbreviated TDF). [33]
Tenofovir alafenamide fumarate (TAF) is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir, the active agent in Viread ® (tenofovir disoproxil fumarate). Phase 1b dose ...
Gilead Initiates Phase 3 Clinical Program for Tenofovir Alafenamide, a Novel Low-Dose Prodrug for the Treatment of HIV -- Two Studies Will Compare a Tenofovir Alafenamide-Based Single Tablet ...
Tenofovir alafenamide (TAF) is a prodrug of tenofovir that functions as a nucleotide reverse transcriptase inhibitor (NtRTI). Other prodrugs for tenofovir have been tested, but TAF is more efficient at refining HIV-1 therapy. It converts intracellularly to TFV diphosphate, which is a metabolite in HIV target cells. [19]
New or worsening kidney problems, including kidney failure Onset of depressive disorders or mood changes Changes in bone such as osteonecrosis (breakdown and death of bone)
Tenofovir, also known as TDF is a so-called 'prodrug' with the active compound deactivated by a molecular side chain that dissolves in the human body allowing a low dose of tenofovir to reach the site of desired activity. One example of the prodrug form is tenofovir disoproxil fumarate with the trade name Viread (Gilead Sciences Inc USA).