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ICV injection of α-Interferon has been used for the treatment of intracranial malignancies in the clinic. α-Interferon has antiviral, antibacterial, and immunostimulatory properties. However, severe central nervous system symptoms occur after injection for ICV, intravenous, and intramuscular routes of administration.
Akinesia and anesthesia quickly ensue within minutes with a successful retrobulbar injection. Retrobulbar block can be used successfully for corneal transplantation but may require a supplemental facial nerve block. Retrobulbar block can block levator palpebrae muscle but not orbicularis oculi.
Hydrodynamic Delivery (HD) is a method of DNA insertion in rodent models. Genes are delivered via injection into the bloodstream of the animal, and are expressed in the liver. This protocol is helpful to determine gene function, regulate gene expression, and develop pharmaceuticals in vivo. [1] W. Heston giving an intravenous injection to mice.
Retrograde tracing can be achieved through various means, including the use of viral strains as markers of a cell's connectivity to the injection site. The pseudorabies virus (PRV; Bartha strain), for example, may be used as a suitable tracer due to the propensity of the infection to spread upstream through a pathway of synaptically linked ...
Intrathecal administration is a route of administration for drugs via an injection into the spinal canal, or into the subarachnoid space so that it reaches the cerebrospinal fluid (CSF). It is useful in several applications, such as for spinal anesthesia, chemotherapy, or pain management. This route is also used to introduce drugs that fight ...
Beginning in 1937 Batson began a series of injection experiments investigating the anatomy and physiology of the cerebrospinal venous system. [2] His carefully documented results demonstrated the continuity of the venous systems of the brain and the spine, as injections of contrast dyes into venous systems feeding into the spinal venous plexus led to the appearance of contrast material in the ...
The inferior ophthalmic vein passes posterior-ward through the inferior orbit [4] upon the inferior rectus muscle.It passes across (not through) the inferior orbital fissure before either draining into the superior ophthalmic vein within the orbit, or passing through or below the common tendinous ring and exiting the orbit through the superior orbital fissure to empty into the cavernous sinus.
The ependyma and vascular pia mater – the tela choroidea, form regions of minute projections known as a choroid plexus that projects into each ventricle. [ 1 ] [ 2 ] The choroid plexus produces most of the cerebrospinal fluid of the central nervous system that circulates through the ventricles of the brain, the central canal of the spinal ...