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Nicotinamide (INN, BAN UK [2]) or niacinamide (USAN US) is a form of vitamin B 3 found in food and used as a dietary supplement and medication. [ 3 ] [ 4 ] [ 5 ] As a supplement, it is used orally (swallowed by mouth) to prevent and treat pellagra (niacin deficiency). [ 4 ]
Example of a label showing the amount of niacin (Vitamin B3), and specifying to be niacinamide in the ingredient section.. The United States adopted in 1942 the terms niacin to nicotinic acid and niacinamide to nicotinamide to avoid references to nicotine, [12] [13] the terms were incorporated into the United States Adopted Name [14] that was created later in 1961.
Niacin is composed of two structures: nicotinic acid and nicotinamide. There are two co-enzyme forms of niacin: nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). Both play an important role in energy transfer reactions in the metabolism of glucose, fat and alcohol. [13]
Nicotinamide mononucleotide ("NMN" and "β-NMN") is a nucleotide derived from ribose, nicotinamide, nicotinamide riboside and niacin. [1] In humans, several enzymes ...
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Nicotinamide riboside (NR, SR647) is a pyridine-nucleoside and a form of vitamin B 3. It functions as a precursor to nicotinamide adenine dinucleotide , or NAD+ , [ 2 ] through a two-step and a three-step pathway.
Nicotinamide adenine dinucleotide consists of two nucleosides joined by pyrophosphate. The nucleosides each contain a ribose ring, one with adenine attached to the first carbon atom (the 1' position) (adenosine diphosphate ribose) and the other with nicotinamide at this position. [4] [5] The redox reactions of nicotinamide adenine dinucleotide
10135 59027 Ensembl ENSG00000105835 ENSMUSG00000020572 UniProt P43490 Q99KQ4 RefSeq (mRNA) NM_005746 NM_182790 NM_021524 RefSeq (protein) NP_005737 NP_067499 Location (UCSC) Chr 7: 106.25 – 106.29 Mb Chr 12: 32.87 – 32.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse nicotinamide phosphoribosyltransferase Identifiers EC no. 2.4.2.12 CAS no. 9030-27-7 Databases IntEnz IntEnz view ...