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Any piece of DNA with the point centromere DNA sequence on it will typically form a centromere if present in the appropriate species. The best characterized point centromeres are those of the budding yeast, Saccharomyces cerevisiae. "Regional centromeres" is the term coined to describe most centromeres, which typically form on regions of ...
Each chromatid has a special region, named the centromere, on top of which is assembled a proteic structure termed kinetochore, which is able to stabilize the microtubule plus end. Therefore, if by chance a microtubule exploring the center of the cell encounters a kinetochore, it may happen that the kinetochore will capture it, so that the ...
centromere A specialized DNA sequence within a chromosome that links a pair of sister chromatids. The primary function of the centromere is to act as the site of assembly for kinetochores, protein complexes which direct the attachment of spindle fibers to the centromere and facilitate segregation of the chromatids during mitosis or meiosis.
M phase See mitosis. macromolecule Any very large molecule composed of dozens, hundreds, or thousands of covalently bonded atoms, especially one with biological significance. . Many important biomolecules, such as nucleic acids and proteins, are polymers consisting of a repeated series of smaller monomers; others such as lipids and carbohydrates may not be polymeric but are nevertheless large ...
However, the emergence of research in neocentromeres troubles this conventional definition and questions the function of a centromere beyond being a “landing pad” for kinetochore formation. [4] This expands the scope of the centromere's function to include regulating the function of the kinetochore and the mitotic spindle .
During cell division, the identical copies (called a "sister chromatid pair") are joined at the region called the centromere (2). Once the paired sister chromatids have separated from one another (in the anaphase of mitosis) each is known as a daughter chromosome. The short arm of the right chromatid (3), and the long arm of the right chromatid ...
an inner kinetochore, which is tightly associated with the centromere DNA and assembled in a specialized form of chromatin that persists throughout the cell cycle; an outer kinetochore, which interacts with microtubules ; the outer kinetochore is a very dynamic structure with many identical components, which are assembled and functional only ...
A simple machine is a mechanical device that changes the direction or magnitude of a force. [1] In general, they can be defined as the simplest mechanisms that use mechanical advantage (also called leverage) to multiply force. [2] Usually the term refers to the six classical simple machines that were defined by Renaissance scientists: [3] [4 ...