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n/a Ensembl ENSG00000228964 ENSG00000234745 ENSG00000206450 ENSG00000224608 ENSG00000223532 ENSG00000232126 n/a UniProt P01889 n/a RefSeq (mRNA) NM_005514 n/a RefSeq (protein) NP_005505 n/a Location (UCSC) Chr 6: 31.35 – 31.37 Mb n/a PubMed search n/a Wikidata View/Edit Human HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein ...
Schematic representation of transmembrane proteins: 1) a single-pass membrane protein 2) a multipass membrane protein (α-helix) 3) a multipass membrane protein β-sheet. The membrane is represented in light yellow. A transmembrane protein is a type of integral membrane protein that spans the entirety of the cell membrane.
Although membrane proteins play an important role in all organisms, their purification has historically, and continues to be, a huge challenge for protein scientists. In 2008, 150 unique structures of membrane proteins were available, [14] and by 2019 only 50 human membrane proteins had had their structures elucidated. [13]
P protein, also known as melanocyte-specific transporter protein or pink-eyed dilution protein homolog, is a protein that in humans is encoded by the oculocutaneous albinism II (OCA2) gene. [5] The P protein is believed to be an integral membrane protein involved in small molecule transport, specifically of tyrosine —a precursor of melanin .
Illustration of a eukaryotic cell membrane Comparison of a eukaryotic vs. a prokaryotic cell membrane. The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space).
Hence, the layer is called a phospholipid bilayer, or sometimes a fluid mosaic membrane. Embedded within this membrane is a macromolecular structure called the porosome the universal secretory portal in cells and a variety of protein molecules that act as channels and pumps that move different molecules into and out of the cell. [2]
Neurofibromin (NF-1) is a protein that is encoded in humans, in the NF1 gene. [5] NF1 is located on chromosome 17. [ 6 ] [ 7 ] [ 8 ] Neurofibromin, a GTPase-activating protein that negatively regulates RAS/MAPK pathway activity by accelerating the hydrolysis of Ras -bound GTP .
The nuclear envelope, also known as the nuclear membrane, [1] [a] is made up of two lipid bilayer membranes that in eukaryotic cells surround the nucleus, which encloses the genetic material. The nuclear envelope consists of two lipid bilayer membranes: an inner nuclear membrane and an outer nuclear membrane. [ 4 ]