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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells , but also acts on haemopoietic progenitor cells and T cells .
Hepatocyte growth factor receptor (HGF receptor) [5] [6] is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. [ 7 ] The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.
Acute-phase serum amyloid A proteins (A-SAAs) are secreted during the acute phase of inflammation.These proteins have several roles, including the transport of cholesterol to the liver for secretion into the bile, the recruitment of immune cells to inflammatory sites, and the induction of enzymes that degrade extracellular matrix.
Tumor markers can be molecules that are produced in higher amounts by cancer cells than normal cells, but can also be produced by other cells from a reaction with the cancer. [ 2 ] The markers can't be used to give patients a diagnosis but can be compared with the result of other tests like biopsy or imaging.
Skin cancer is the most commonly diagnosed form of cancer in humans. [11] [12] [13] There are three main types of skin cancers: basal-cell skin cancer (BCC), squamous-cell skin cancer (SCC) and melanoma. [1] The first two, along with a number of less common skin cancers, are known as nonmelanoma skin cancer (NMSC).
Fibroblast growth factor 21 (FGF-21) is a protein that in mammals is encoded by the FGF21 gene. [5] [6] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the endocrine subfamily which includes FGF23 and FGF15/19.
Growth factor is sometimes used interchangeably among scientists with the term cytokine. [3] Historically, cytokines were associated with hematopoietic (blood and lymph forming) cells and immune system cells (e.g., lymphocytes and tissue cells from spleen, thymus, and lymph nodes).
17311 Ensembl ENSG00000049130 ENSMUSG00000019966 UniProt P21583 P20826 RefSeq (mRNA) NM_003994 NM_000899 NM_013598 NM_001347156 RefSeq (protein) NP_000890 NP_003985 NP_001334085 NP_038626 Location (UCSC) Chr 12: 88.49 – 88.58 Mb Chr 10: 99.85 – 99.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine ...