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The binding constant, or affinity constant/association constant, is a special case of the equilibrium constant K, [1] and is the inverse of the dissociation constant. [2] It is associated with the binding and unbinding reaction of receptor (R) and ligand (L) molecules, which is formalized as: R + L ⇌ RL
The electron affinity of molecules is a complicated function of their electronic structure. For instance the electron affinity for benzene is negative, as is that of naphthalene, while those of anthracene, phenanthrene and pyrene are positive. In silico experiments show that the electron affinity of hexacyanobenzene surpasses that of fullerene. [5]
For accurate measurements of binding affinity, the curve of the thermogram must be sigmoidal. A steep sigmoidal curve signals a strong binding whereas a less steep sigmoidal curve points to a weaker binding. [4] The profile of the curve is determined by the c-value, which is calculated using the equation: =
Also known as the two-site Langmuir equation. This equation describes the adsorption of one adsorbate to two or more distinct types of adsorption sites. Each binding site can be described with its own Langmuir expression, as long as the adsorption at each binding site type is independent from the rest.
MST provides information regarding the binding affinity, stoichiometry, competition and enthalpy of two or more interacting proteins. [31] [32] Rotating cell‑based ligand binding assay using radioactivity or fluorescence, is a recent method that measures molecular interactions in living cells in real-time.
The bond-dissociation energy of a carbon-carbon bond is about 3.6 eV. Molecular level: Electron binding energy; Ionization energy Electron binding energy, more commonly known as ionization energy, [3] is a measure of the energy required to free an electron from its atomic orbital or from a solid.
Ligand efficiency is a measurement of the binding energy per atom of a ligand to its binding partner, such as a receptor or enzyme. [1]Ligand efficiency is used in drug discovery research programs to assist in narrowing focus to lead compounds with optimal combinations of physicochemical properties and pharmacological properties.
In coordination chemistry, a stability constant (also called formation constant or binding constant) is an equilibrium constant for the formation of a complex in solution. It is a measure of the strength of the interaction between the reagents that come together to form the complex. There are two main kinds of complex: compounds formed by the ...